Women's Health
Progesterone (Oral Micronized)
Sleep, calm, and uterine protection — the other half of HRT.
Bioidentical oral micronized progesterone (Prometrium-equivalent) — required to protect the uterine lining when you're on estrogen, and often prescribed on its own at bedtime for sleep, anxiety, and perimenopausal mood shifts.
Starting at
$49/mo
Best for
- Women on estradiol who still have a uterus (endometrial protection)
- Perimenopausal women with sleep disruption, anxiety, or short luteal phases
- Women who tolerated progesterone better than synthetic progestins (e.g. medroxyprogesterone)
Not for
- Known or suspected pregnancy
- Severe liver disease
- Active thromboembolic disease
- Peanut allergy (most oral micronized progesterone is suspended in peanut oil) — ask for an alternative
How it works
What it is — and what it isn't.
Oral micronized progesterone is bioidentical to the progesterone your ovaries produce after ovulation. Taken at bedtime, it converts in part to allopregnanolone, a GABA-A modulator — which is why so many women report calmer sleep on it. In combined HRT it balances estrogen's effect on the endometrium, sharply reducing endometrial hyperplasia and cancer risk.
Typical protocol
How a course usually unfolds.
Your clinician personalizes the actual schedule based on your goals, history, and response.
- 1
Week 0
Telehealth intake — confirm uterine status, sleep patterns, and any peanut allergy.
- 2
Week 1–4
Start 100–200 mg at bedtime, continuous or cyclical depending on menopause stage.
- 3
Week 6–12
Check-in on sleep, mood, bleeding pattern. Adjust dose or schedule.
- 4
Ongoing
Annual review alongside estradiol monitoring.
What's included
One flat price. Everything you need.
We bundle the whole experience — clinician care, medication, shipping, and adjustments.
- Provider visit & ongoing messaging
- Medication shipped free in discreet packaging
- Dose adjustments based on your response
- Cancel or pause anytime
Safety & side effects
What to know — straight, not scary.
Common
- Drowsiness (intentional — take at bedtime)
- Mild dizziness on standing
- Breast tenderness
- Spotting in first cycles
Less common / serious
- Allergic reaction (peanut-oil base) — switch to alternative formulation
- Worsening depression in a minority of patients
- Rare clotting events when combined with estrogen
Always message your clinician about side effects — most can be managed with dose adjustment, timing, or hydration support.
FAQs
Questions worth asking.
See if Progesterone (Oral Micronized) is right for you.
Three-minute assessment. Free clinician review. No insurance needed.
Start my assessmentFree 3-min assessment · Texas-licensed clinicians · No insurance needed.