Will it work for everyone?

No. Men with primary testicular failure won't respond well — that's what labs (LH, FSH) tell us. We reassess at 8–12 weeks and switch protocols if it isn't moving your numbers.

Clomiphene (Clomid) is a 50/50 mix of two isomers; enclomiphene is the trans-isomer only — designed to give the testosterone-raising effect with fewer mood and estrogenic side effects.

Home Men's HealthEnclomiphene

Men's Health

Enclomiphene

Raise your own testosterone — without shutting down fertility.

An oral SERM that signals your pituitary to produce more LH and FSH, raising natural testosterone while preserving sperm production. A common alternative to TRT for younger men or those who may want kids.

Starting at

$89/mo

Start my assessment

US clinicians

Free shipping

Care included

Best for

Men with low or low-normal T who want to preserve fertility
Patients hesitant to start lifelong injectable TRT
Secondary hypogonadism (low T from pituitary signaling, not testicular failure)

Not for

Primary testicular failure (enclomiphene needs a working pituitary-testis axis)
Men with active hormone-sensitive cancer
Untreated thromboembolic disease

How it works

What it is — and what it isn't.

Enclomiphene is the trans-isomer of clomiphene. It blocks estrogen receptors at the pituitary, which increases LH and FSH release — telling your testes to produce more testosterone and sperm. Unlike TRT, it works with your own endocrine system rather than replacing it.

Typical protocol

How a course usually unfolds.

Your clinician personalizes the actual schedule based on your goals, history, and response.

1
Week 0
Baseline labs (total/free T, LH, FSH, estradiol, CBC) and clinician intake.
2
Week 1–8
Daily oral dose, typically 12.5–25 mg.
3
Week 8–12
Recheck labs. Adjust dose or move to TRT if response is inadequate.
4
Ongoing
Labs every 6 months, ongoing clinician messaging.

What's included

One flat price. Everything you need.

We bundle the whole experience — clinician care, medication, shipping, and adjustments.

Provider visit & ongoing messaging
Medication shipped free in discreet packaging
Dose adjustments based on your response
Cancel or pause anytime
Baseline + follow-up lab orders (lab fees billed separately)

Safety & side effects

What to know — straight, not scary.

Common

Mood changes
Mild visual disturbance (rare)
Hot flashes
Headache

Less common / serious

Vision changes (stop and call clinician)
Mood/anxiety shifts
Thromboembolic events (rare)

Always message your clinician about side effects — most can be managed with dose adjustment, timing, or hydration support.

FAQs

Questions worth asking.

If you want to preserve fertility, are younger, or your low T is from pituitary signaling rather than testicular failure, enclomiphene is often the first move. If your testes can't respond regardless of signal, TRT is the right tool. Your clinician will use labs to decide.

See if Enclomiphene is right for you.

Three-minute assessment. Free clinician review. No insurance needed.